The science behind the GOOD and BAD cholesterol. Your body makes all the cholesterol it needs. At normal levels, it is an essential substance for the body. Disturbances in cholesterol metabolism cause various diseases. Cholesterol has a bad reputation, thanks to its well-known role in promoting heart disease. The American Heart Association explains how cholesterol affects the heart. Cholesterol content in the bloodstream is regulated by the liver. HDL metabolism is complex, but one role of HDL is to obtain cholesterol from peripheral tissues and other lipoproteins and transport it to where it is needed most—other cells, other lipoproteins (using cholesteryl ester transfer protein [CETP]), and the liver (for clearance). But cholesterol is necessary for the creation of hormones, vitamin D, and enzymes needed for digestion. A cholesterol test will measure the total cholesterol in your blood, and your total cholesterol levels are made up of a combination of your LDL, HDL, and VLDL (very low density lipoprotein, another "bad" cholesterol) levels. Your body needs some cholesterol to make hormones, vitamin D, and substances that help you digest foods. Cholesterol metabolism 1. A total cholesterol score of 200 mg/dL or lower is considered optimal. Hypercholesterolemia. Cholesterol metabolism : Cholesterol is readily oxidized to form Oxysterols. CHOLESTEROL PRESENTED BY:-SILENT KILLERS 2. Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Its overall effect is … Cholesterol transport and pathways, drugs used for treatment of atherosclerosis. Excess cholesterol in the bloodstream is a key contributor to artery-clogging plaque, which can accumulate and set the stage for a heart attack. The excess cholesterol produced in this way activates acetyl-CoA cholesterol acyl-transferase (ACAT), which re-esterifies cholesterol into cholesterol esters that can be deposited as lipid droplets or mobilized again to where it is needed. As the body requires cholesterol, it may be secreted by the liver. Cholesterol can be oxidized in three ways as follows : Autooxidation, Secondary Oxidation and Cholesterol-metabolizing Enzyme Oxidation. What is cholesterol? Learn about prevention and treatment of high cholesterol, triglycerides, ldl, hdl, athersclerosis, arteriosclerosis, hypercholesterolemia, bad cholesterol, reducing cholesterol, cholesterol screening, cholesterol tracker, recipes and preventing high cholesterol. Metabolic disease - Metabolic disease - Disorders of lipid metabolism: Lipids are large, water-insoluble molecules that have a variety of biological functions, including storing energy and serving as components of cellular membranes and lipoproteins. 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